Journal article

Predicting experimentally-derived failure load at the distal radius using finite element modelling based on peripheral quantitative computed tomography cross-sections (pQCT-FE): A validation study

Hongyuan Jiang, Dale L Robinson, Matthew McDonald, Peter VS Lee, Saija A Kontulainen, James D Johnston, Christopher J Yates, John D Wark

Bone | ELSEVIER SCIENCE INC | Published : 2019

Abstract

Dual energy X-ray absorptiometry, the current clinical criterion method for osteoporosis diagnosis, has limitations in identifying individuals with increased fracture risk, especially at the distal radius. Peripheral quantitative computed tomography (pQCT) can provide volumetric bone density data, as well as information on bone geometry, which makes it possible to establish finite element (FE) models of the distal radius from which bone strength and stiffness can be calculated. In this study, we compared experimental mechanical failure load data of the forearm with pQCT- based FE (pQCT-FE) modelling properties. Sixteen cadaveric forearm specimens were experimentally loaded until failure. Est..

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Grants

Awarded by Natural Sciences and Engineering Research Council of Canada (NSERC)


Awarded by Saskatchewan Health Research Foundation (SHRF)


Awarded by China Scholarship Council


Funding Acknowledgements

This work was supported by the Natural Sciences and Engineering Research Council of Canada (NSERC Discovery Grant RGPIN-2016-05301, SK) and Saskatchewan Health Research Foundation (SHRF Establishment Grant 2632, JDJ). HJ was funded under a joint PhD scholarship by China Scholarship Council (funding reference: CSC201608240003) and the University of Melbourne.