Sex differences in risk factors for aneurysmal subarachnoid haemorrhage: Systematic review and meta-analysis

S Rehman; BW Sahle; RV Chandra; M Dwyer; AG Thrift; M Callisaya; M Breslin; HT Phan; P Otahal; S Gall

Conference Proceedings

Sex differences in risk factors for aneurysmal subarachnoid haemorrhage: Systematic review and meta-analysis

S Rehman, BW Sahle, RV Chandra, M Dwyer, AG Thrift, M Callisaya, M Breslin, HT Phan, P Otahal, S Gall

Journal of the Neurological Sciences | ELSEVIER | Published : 2019

DOI: 10.1016/j.jns.2019.116446

Abstract

Background: Aneurysmal subarachnoid haemorrhage (aSAH) disproportionally affects women. We conducted a systematic review and meta-analysis to explore sex differences in aSAH risk factors. Methods: Case-control/cohort studies were searched to November 2017 with sex-specific risk factors for aSAH. Meta-analysis was performed when a risk factor was reported in ≥2 studies. Results: Of 31 studies, 22 were eligible for meta-analysis. Female sex was associated with greater odds of aSAH (HRadjusted 1.90 [1.47–2.46]. There was no detectable difference between the sexes for hypertension (ORadjusted: men 3.13 [2.26–4.34]; women 3.65 [2.87–4.63], p = .18), smoking (ORadjusted: men 2.96 [1.68–5.21]; wome..

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University of Melbourne Researchers

Berhe Sahle Author

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

Sabah Rehman is funded by University of Tasmania, Menzies Institute for Medical Research Tasmania Graduate Research Scholarship co-funded/no disclosures to report.Mitchell Dwyer is funded by University of Tasmania/no disclosures to report.Amanda G. Thrift is funded by a National Health and Medical Research Council (Australia) fellowship [1042600]. Dr. Thrift reports grants from National Health and Medical Research Council (NHMRC), Australia, during the conduct of the study; grants from NHMRC, outside the submitted work.Michele Callisaya is funded by a National Health and Medical Research Council Boosting Dementia Leaderships research fellowship [1135761]/no disclosures to report.Seana Gall is funded by National Heart Foundation of Australia Future Leader Fellowship [FLF 100446]. Dr. Gall reports grants from National Health and Medical Research Council, grants from National Heart Foundation of Australia, during the conduct of the study.