Genetic Correlations Between Diabetes and Glaucoma: An Analysis of Continuous and Dichotomous Phenotypes

Vincent Laville; Jae H Kang; Clara C Cousins; Adriana I Iglesias; Reka Nagy; Jessica N Cooke Bailey; Robert P Igo; Yeunjoo E Song; Daniel I Chasman; William G Christen; Peter Kraft; Bernard A Rosner; Frank Hu; James F Wilson; Puya Gharahkhani; Alex W Hewitt; David A Mackey; Pirro G Hysi; Christopher J Hammond; Cornelia M Vanduijn; Jonathan L Haines; Veronique Vitart; John H Fingert; Michael A Hauser; Hugues Aschard; Janey L Wiggs; Anthony P Khawaja; Stuart Macgregor; Louis R Pasquale

Journal article

Genetic Correlations Between Diabetes and Glaucoma: An Analysis of Continuous and Dichotomous Phenotypes

Vincent Laville, Jae H Kang, Clara C Cousins, Adriana I Iglesias, Reka Nagy, Jessica N Cooke Bailey, Robert P Igo, Yeunjoo E Song, Daniel I Chasman, William G Christen, Peter Kraft, Bernard A Rosner, Frank Hu, James F Wilson, Puya Gharahkhani, Alex W Hewitt, David A Mackey, Pirro G Hysi, Christopher J Hammond, Cornelia M Vanduijn Show all

American Journal of Ophthalmology | ELSEVIER SCIENCE INC | Published : 2019

DOI: 10.1016/j.ajo.2019.05.015

Abstract

PURPOSE: A genetic correlation is the proportion of phenotypic variance between traits that is shared on a genetic basis. Here we explore genetic correlations between diabetes- and glaucoma-related traits. DESIGN: Cross-sectional study. METHODS: We assembled genome-wide association study summary statistics from European-derived participants regarding diabetes-related traits like fasting blood sugar (FBS) and type 2 diabetes (T2D) and glaucoma-related traits (intraocular pressure (IOP), central corneal thickness (CCT), corneal hysteresis (CH), corneal resistance factor (CRF), cup-disc ratio (CDR), and primary open-angle glaucoma (POAG)). We included data from the National Eye Institute Glauco..

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University of Melbourne Researchers

David Mackey Author Ophthalmology Eye and Ear Hospital

Grants

Awarded by National Eye Institute

Awarded by Australian National Health and Medical Research Council

Funding Acknowledgements

Supported by National Eye Institute Grants EY015473 (Dr Pasquale) and P30 EY014104 and EY022305 (Dr Wiggs). Dr Khawaja is supported by a Moorfields Eye Charity Career Development Fellowship. Dr MacGregor was supported by an Australian Research Council Fellowship. Drs MacGregor, Mackey, and Hewitt acknowledge grants 1150144 and 1116360 from the Australian National Health and Medical Research Council.