Autocrine IFN-I inhibits isocitrate dehydrogenase in the TCA cycle of LPS-stimulated macrophages

David P De Souza; Adrian Achuthan; Man KS Lee; Katrina J Binger; Ming-Chin Lee; Sophia Davidson; Dedreia L Tull; Malcolm J McConville; Andrew D Cook; Andrew J Murphy; John A Hamilton; Andrew J Fleetwood

Journal article

Autocrine IFN-I inhibits isocitrate dehydrogenase in the TCA cycle of LPS-stimulated macrophages

David P De Souza, Adrian Achuthan, Man KS Lee, Katrina J Binger, Ming-Chin Lee, Sophia Davidson, Dedreia L Tull, Malcolm J McConville, Andrew D Cook, Andrew J Murphy, John A Hamilton, Andrew J Fleetwood

Journal of Clinical Investigation | AMER SOC CLINICAL INVESTIGATION INC | Published : 2019

DOI: 10.1172/JCI127597

University of Melbourne Researchers

Malcolm McConville Author Biochemistry and Molecular Biology

Andrew Fleetwood Author Medicine - Royal Melbourne Hospital

Andrew Murphy Author Baker Department of Cardiometabolic Health

David de Souza Author Bio21 Institute

Sophia Davidson Author Medical Biology (W.E.H.I.)

Grants

Awarded by National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

This work was supported by National Health and Medical Research Council (NHMRC) grants (APP1107001 and APP1159901). MJM is an NHMRC Principal Research Fellow.