Journal article
Telomere length and lung function in a population-based cohort of children and mid-life adults
MT Nguyen, R Saffery, D Burgner, K Lycett, R Vryer, A Grobler, T Dwyer, S Ranganathan, M Wake
Pediatric Pulmonology | WILEY | Published : 2019
DOI: 10.1002/ppul.24489
Abstract
Objective: Telomere length is associated with poorer lung health in older adults, possibly from cumulative risk factor exposure, but data are lacking in pediatric and population-based cohorts. We examined associations of telomere length with lung function in children and mid-life adults. Methods: Data were drawn from a population-based cross-sectional study of 11 to 12 year-olds and mid-life adults. Lung function was assessed by spirometric FEV1, FVC, FEV 1/FVC ratio, and MMEF 25-75. Telomere length was measured by quantitative polymerase chain reaction from blood and expressed as the amount of telomeric genomic DNA to the beta-globin gene (T/S ratio). Associations of telomere length with sp..
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Awarded by National Institutes of Health
Funding Acknowledgements
Murdoch Children's Research Institute, Grant/Award Number: Clinician Scientist Award; The University of Melbourne; Australian National Health and Medical Research Council, Grant/Award Numbers: Early Career Fellowship 1091124, Postgraduate Scholarship 1115167, Principal Research Fellowship 1160906, Project Grant 1041352, Project Grant 1109355, Research Fellowship 1064629, Senior Research Fellowship 1045161, Senior Research Fellowship 1046518; Australian National Heart Foundation, Grant/Award Numbers: 100660, Honorary Future Leader Fellowship 100369, Postdoctoral Fellowship 101239; Cure Kids New Zealand; Financial Markets Foundation for Children, Grant/Award Numbers: 2014-055, 2016-310; The Royal Children's Hospital