Journal article
The genetic relationship between educational attainment and cognitive performance in major psychiatric disorders
AL Comes, F Senner, M Budde, K Adorjan, H Anderson-Schmidt, TFM Andlauer, K Gade, M Hake, U Heilbronner, JL Kalman, D Reich-Erkelenz, F Klöhn-Saghatolislam, SK Schaupp, EC Schulte, G Juckel, U Dannlowski, M Schmauß, J Zimmermann, J Reimer, E Reininghaus Show all
Translational Psychiatry | SPRINGERNATURE | Published : 2019
Abstract
Cognitive deficits are a core feature of psychiatric disorders like schizophrenia and bipolar disorder. Evidence supports a genome-wide polygenic score (GPS) for educational attainment (GPSEDU) can be used to explain variability in cognitive performance. We aimed to identify different cognitive domains associated with GPSEDU in a transdiagnostic clinical cohort of chronic psychiatric patients with known cognitive deficits. Bipolar and schizophrenia patients from the PsyCourse cohort (N = 730; 43% female) were used. Likewise, we tested whether GPSs for schizophrenia (GPSSZ) and bipolar disorder (GPSBD) were associated with cognitive outcomes. GPSEDU explained 1.5% of variance in the backward ..
View full abstractGrants
Awarded by Interdisziplinäres Zentrum für Klinische Forschung, Universitätsklinikum Würzburg
Funding Acknowledgements
Thomas G. Schulze and Peter Falkai are supported by the German Research Foundation (Deutsche Forschungsgemeinschaft; DFG) within the framework of the projects www.kfo241.de and www.PsyCourse.de (SCHU 1603/4-1, 5-1, 7-1; FA241/16-1). The genotyping was in part funded by the German Federal Ministry of Education and Research (BMBF) through the Integrated Network IntegraMent (Integrated Understanding of Causes and Mechanisms in Mental Disorders), under the auspices of the e: Med Program with grants awarded to Thomas G. Schulze (01ZX1614K), Marcella Rietschel (01ZX1614G), and Markus M. Nothen (01ZX1614A). Thomas G. Schulze received additional support from the German Federal Ministry of Education and Research (BMBF) within the framework of the BipoLife network (01EE1404H) and the Dr. Lisa Oehler Foundation (Kassel, Germany). Sergi Papiol was supported by a 2016 NARSAD Young Investigator Gra\nt (25015) from the Brain and Behavior Research Foundation. Marcella Rietschel and Markus M. Nothen received funding from the German Research Foundation (DFG, grant FOR2107; RI 908/11-2 to Marcella Rietschel, NO 246/10-2 to Markus M. Nothen). Franziska Degenhardt received support from the BONFOR Programme of the University of Bonn, Germany. Jens Wiltfang is supported by an Ilidio Pinho professorship and iBiMED (UID/BIM/04501/2013), at the University of Aveiro. Udo Dannlowski was funded by the German Research Foundation (DFG, grant FOR2107 DA1151/5-1; SFB-TRR58, Project C09) and the Interdisciplinary Center for Clinical Research (IZKF) of the medical faculty of Munster (grant Dan3/012/17 to Udo Dannlowski). Volker Arolt was funded by the European Union FP-7 Research Grant MOODINFLAME. We would like to express our profound gratitude to all study participants without whom this work would not have been possible.