Journal article

Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals

Pauline Favre, Melissa Pauling, Jacques Stout, Franz Hozer, Samuel Sarrazin, Christoph Abe, Martin Alda, Clara Alloza, Silvia Alonso-Lana, Ole A Andreassen, Bernhard T Baune, Francesco Benedetti, Geraldo F Busatto, Erick J Canales-Rodriguez, Xavier Caseras, Tiffany Moukbel Chaim-Avancini, Christopher RK Ching, Udo Dannlowski, Michael Deppe, Lisa T Eyler Show all

NEUROPSYCHOPHARMACOLOGY | NATURE PUBLISHING GROUP | Published : 2019

Abstract

Fronto-limbic white matter (WM) abnormalities are assumed to lie at the heart of the pathophysiology of bipolar disorder (BD); however, diffusion tensor imaging (DTI) studies have reported heterogeneous results and it is not clear how the clinical heterogeneity is related to the observed differences. This study aimed to identify WM abnormalities that differentiate patients with BD from healthy controls (HC) in the largest DTI dataset of patients with BD to date, collected via the ENIGMA network. We gathered individual tensor-derived regional metrics from 26 cohorts leading to a sample size of N = 3033 (1482 BD and 1551 HC). Mean fractional anisotropy (FA) from 43 regions of interest (ROI) an..

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University of Melbourne Researchers

Grants

Awarded by German Research Foundation (DFG)


Awarded by Interdisciplinary Center for Clinical Research (IZKF) of the medical faculty of Munster


Awarded by German Research Foundation


Awarded by Research Council of Norway


Awarded by NIH


Awarded by South East Norway Health Authority


Awarded by Kristian Gerhard Jebsen Stiftelsen


Awarded by European Community's Seventh Framework Program (FP7/2007-2013)


Awarded by Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, Brazil)


Awarded by Australian National Medical and Health Research Council


Awarded by NIH from the BD2K Initiative


Awarded by NHG


Awarded by SBIC


Awarded by Canadian Institutes of Health Research


Awarded by NARSAD Young Investigator Award


Awarded by Spanish Ministry of Science, Innovation and Universities


Awarded by Comissionat per a Universitats i Recerca del DIUE de la Generalitat de Catalunya


Awarded by PERIS 2016-2020 (Departament de Salut)


Awarded by FAPESP-Brazil


Awarded by CNPqBrazil


Awarded by NIA


Awarded by NIH/NIMH


Awarded by NIH from the Big Data to Knowledge (BD2K) Program


Awarded by Human Brain Project - European Union's Horizon 2020 Framework Program for Research and Innovation


Awarded by FRM


Awarded by grant "Infrastructure d'avenir en Biologie Sante"


Awarded by Agence Nationale pour la Recherche


Awarded by NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING


Awarded by NATIONAL INSTITUTE ON AGING


Funding Acknowledgements

The researchers and studies included in this paper were funded by the: German Research Foundation (DFG, grant FOR2107 DA1151/5-1 and DA1151/5-2 to UD; SFB-TRR58, Projects C09 and Z02 to UD) and the Interdisciplinary Center for Clinical Research (IZKF) of the medical faculty of Munster (grant Dan3/012/17 to UD); German Research Foundation (SFB636/C6, WE3638/3-1); Oslo University Hospital, University of Oslo, Norwegian Research Council, South Eastern Norwegian Health Authorities; NIH Grant MH083968; VA Desert-Pacific Mental Illness Research Education and Clinical Center; Research Council of Norway (223273, 213837, 249711, 249795, 248238, 248778, and 262656), South East Norway Health Authority (2017-112) Kristian Gerhard Jebsen Stiftelsen (SKGJ-MED-008) and the European Community's Seventh Framework Program (FP7/2007-2013), grant agreement no. 602450 (IMAGEMEND); Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, Brazil, 480370/2009-5); Australian National Medical and Health Research Council (Program Grant 1037196), and the Lansdowne Foundation; NIH grant U54 EB020403 from the BD2K Initiative, R01 MH116147, and P41 EB015922; CIBERSAM; NHG (SIG/12004) and SBIC (RP C-009) (KS); SAMRC (DJS); Canadian Institutes of Health Research (103703, 106469 and 64410); Nova Scotia Health Research Foundation, Dalhousie Clinical Research and Scholarship to T Hajek, NARSAD Young Investigator and Independent Investigator Awards (TH), JMAS SIM fellowship from the Royal College of Physicians of Edinburgh and an ESAT College Fellowship from the University of Edinburgh (HCW); Part of the Cardiff cohort was funded through a NARSAD Young Investigator Award (17319) (XC), we are also grateful to the National Centre for Mental Health (NCMH) and the Bipolar Disorder Research Network for their support with recruitment; Spanish Ministry of Science, Innovation and Universities (PI15/00283) integrated into the Plan Nacional de I+D+I y cofinanciado por el ISCIII-Subdireccion General de Evaluacion y el Fondo Europeo de Desarrollo Regional (FEDER), CIBERSAM, and the Comissionat per a Universitats i Recerca del DIUE de la Generalitat de Catalunya to the Bipolar Disorders Group (2017 SGR 1365) and the project SLT006/17/00357, from PERIS 2016-2020 (Departament de Salut). CERCA Programme/Generalitat de Catalunya (EV); FAPESP-Brazil (#2009/14891-9, 2010/18672-7, 2012/23796-2 and 2013/03905-4), CNPqBrazil (#478466/2009 and 480370/2009), the Wellcome Trust (UK) and the Brain & Behavior Research Foundation (NARSAD Independent Investigator Award (GFB); CRKC was supported by NIA T32AG058507; NIH/NIMH 5T32MH073526 and NIH grant U54EB020403 from the Big Data to Knowledge (BD2K) Program. CRKC has received partial research support from Biogen, Inc. (Boston, USA) for work unrelated to the topic of this manuscript; the Human Brain Project, funded from the European Union's Horizon 2020 Framework Program for Research and Innovation under the Specific Grant Agreements No. 785907 (SGA2) and No: 604102 (SGA1), and by the FRM DIC20161236445; IRMaGe MRI/Neurophysiology facility which was partly funded by the French program "Investissement d'Avenir" run by the "Agence Nationale pour la Recherche"; grant "Infrastructure d'avenir en Biologie Sante"-ANR-11-INBS-0006" and the Agence Nationale pour la Recherche (ANR-11-IDEX-0004 Labex BioPsy, ANR-10-COHO-10-01 psyCOH), Fondation pour la Recherche Medicale (Bioinformatique pour la biologie 2014) and the Fondation de l'Avenir (Recherche Medicale Appliquee 2014). PMT and NJ received research grant from Biogen, Inc., for research unrelated to this manuscript. Dr. Vieta has received grants and served as consultant, advisor or CME speaker for the following entities: AB-Biotics, Abbott, Allergan, Angelini, Dainippon Sumitomo Pharma, Galenica, Janssen, Lundbeck, Novartis, Otsuka, Sage, Sanofi-Aventis, and Takeda. OAA has received speakers honorarium from Lundbeck, and is consultant for HealthLytix. DJS has received research grants and/or consultancy honoraria from Lundbeck and Sun. The remaining authors declare no competing interests.