Journal article

Microscopic and submicroscopic Plasmodium falciparum infection, maternal anaemia and adverse pregnancy outcomes in Papua New Guinea: a cohort study

Holger W Unger, Anna Rosanas-Urgell, Leanne J Robinson, Maria Ome-Kaius, Shadrach Jally, Alexandra J Umbers, Willie Pomat, Ivo Mueller, Eline Kattenberg, Stephen J Rogerson

MALARIA JOURNAL | BMC | Published : 2019

Abstract

BACKGROUND: Infection during pregnancy with Plasmodium falciparum is associated with maternal anaemia and adverse birth outcomes including low birth weight (LBW). Studies using polymerase chain reaction (PCR) techniques indicate that at least half of all infections in maternal venous blood are missed by light microscopy or rapid diagnostic tests. The impact of these subpatent infections on maternal and birth outcomes remains unclear. METHODS: In a cohort of women co-enrolled in a clinical trial of intermittent treatment with sulfadoxine-pyrimethamine (SP) plus azithromycin for the prevention of LBW (< 2500 g) in Papua New Guinea (PNG), P. falciparum infection status at antenatal enrolment an..

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Grants

Awarded by Malaria in Pregnancy Consortium (Bill & Melinda Gates Foundation)


Awarded by Pregvax Consortium (European Union's Seventh Framework Programme FP7-2007-HEALTH)


Awarded by Pfizer Inc. as part of an Investigator-Initiated Research Grant


Funding Acknowledgements

This trial was supported by the Malaria in Pregnancy Consortium (funded by the Bill & Melinda Gates Foundation, 46099), and the Pregvax Consortium (European Union's Seventh Framework Programme FP7-2007-HEALTH, PREG-VAX 201588, and the Spanish Government EUROSALUD 208 Programme). Azithromycin was provided by Pfizer Inc. as part of an Investigator-Initiated Research Grant (WS394663). Funding sources did not have any involvement in study design, collection, analysis, and interpretation of data, and compilation and submission of this report.