Journal article

FRAX (Australia) scores in women with impaired fasting glucose and diabetes

Lelia LF de Abreu, Kara L Holloway-Kew, Muhammad A Sajjad, Mark A Kotowicz, Julie A Pasco

Bone Reports | ELSEVIER | Published : 2019

Abstract

Background: Diabetes is associated with higher fracture risk despite higher bone mineral density (BMD), with FRAX® underestimating risk. This study aimed to investigate FRAX score with and without BMD for women with normoglycaemia, impaired fasting glucose (IFG) and diabetes. Methods: Among 566 women, aged 40-90 years, enrolled in the Geelong Osteoporosis Study, IFG was defined as fasting plasma glucose (FPG) ≥5.5 mmol/L and diabetes as FPG ≥ 7.0 mmol/L, use of antihyperglycaemic medication and/or self-report. FRAX (Australia) 10-year probabilities of major osteoporotic (MOF) and hip fracture were calculated, with and without BMD, producing four FRAX scores per participant. Kruskal-Wallis te..

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University of Melbourne Researchers

Grants

Awarded by National Health and Medical Research Council (NHMRC) Australia


Funding Acknowledgements

All authors declare that they have no conflict of interest. The study was supported by The Victorian Health Promotion Foundation, National Health and Medical Research Council (NHMRC) Australia (projects 251638, 628582), the Geelong Region Medical Research Foundation, LLFA and MAS are supported by Deakin University Postgraduate Awards; KLH is supported by an Alfred Deakin Postdoctoral Research Fellowship, however, the funding bodies played no part in the design or conduct of the study, the collection, management, analysis and interpretation of the data, nor in the preparation or review of the manuscript.