Journal article

Assisted reproductive technologies are associated with limited epigenetic variation at birth that largely resolves by adulthood

Boris Novakovic, Sharon Lewis, Jane Halliday, Joanne Kennedy, David P Burgner, Anna Czajko, Bowon Kim, Alexandra Sexton-Oates, Markus Juonala, Karin Hammarberg, David J Amor, Lex W Doyle, Sarath Ranganatha, Liam Welsh, Michael Cheung, John McBain, Robert McLachlan, Richard Saffery

NATURE COMMUNICATIONS | NATURE PUBLISHING GROUP | Published : 2019

Abstract

More than 7 million individuals have been conceived by Assisted Reproductive Technologies (ART) and there is clear evidence that ART is associated with a range of adverse early life outcomes, including rare imprinting disorders. The periconception period and early embryogenesis are associated with widespread epigenetic remodeling, which can be influenced by ART, with effects on the developmental trajectory in utero, and potentially on health throughout life. Here we profile genome-wide DNA methylation in blood collected in the newborn period and in adulthood (age 22-35 years) from a unique longitudinal cohort of ART-conceived individuals, previously shown to have no differences in health out..

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Grants

Awarded by National Health and Medical Research Council


Awarded by NHMRC (Australia) CJ Martin Fellowship


Awarded by NHMRC Senior Research Fellowship


Funding Acknowledgements

The authors acknowledge the participants who generously gave their time to the study. This work was made possible through the Victorian State Government Operational Infrastructure Support and the Australian Government NHMRC IRIISS. This study was funded by a National Health and Medical Research Council Project Grant (APP1099641; 2016-2017), The Royal Children's Hospital Research Foundation, Monash IVF Research and Education Foundation, and Reproductive Biology Unit Sperm Fund, Melbourne IVF. B.N. is supported by an NHMRC (Australia) CJ Martin Fellowship (1072966). DPB is supported by an NHMRC Senior Research Fellowship (1064629).