Journal article

Z/I1 Hybrid Virulence Plasmids Carrying Antimicrobial Resistance genes in S. Typhimurium from Australian Food Animal Production

Ethan R Wyrsch, Jane Hawkey, Louise M Judd, Ruth Haites, Kathryn E Holt, Steven P Djordjevic, Helen Billman-Jacobe

MICROORGANISMS | MDPI | Published : 2019

Abstract

Knowledge of mobile genetic elements that capture and disseminate antimicrobial resistance genes between diverse environments, particularly across human-animal boundaries, is key to understanding the role anthropogenic activities have in the evolution of antimicrobial resistance. Plasmids that circulate within the Enterobacteriaceae and the Proteobacteria more broadly are well placed to acquire resistance genes sourced from separate niche environments and provide a platform for smaller mobile elements such as IS26 to assemble these genes into large, complex genomic structures. Here, we characterised two atypical Z/I1 hybrid plasmids, pSTM32-108 and pSTM37-118, hosting antimicrobial resistanc..

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Grants

Awarded by Australian Research Council


Funding Acknowledgements

This work was partly funded by the Australian Research Council, linkage grants LP150100912 and LE150100031. This project was supported by the Australian Centre for Genomic Epidemiological Microbiology (AusGEM), a collaborative research partnership between the NSW Department of Primary Industries and the University of Technology Sydney. These results are helping to inform the OUTBREAK decision support system funded by the Medical Research Future Fund Frontier Health and Medical Research grant stage one.