Journal article

Atrazine induces penis abnormalities including hypospadias in mice

Luke C Govers, Alesia P Harper, Bethany J Finger, Deidre M Mattiske, Andrew J Pask, Mark P Green

Journal of Developmental Origins of Health and Disease | CAMBRIDGE UNIV PRESS | Published : 2020

Abstract

Use of the herbicide atrazine (ATR) is banned in the European Union; yet, it is still widely used in the USA and Australia. ATR is known to alter testosterone and oestrogen production and thus reproductive characteristics in numerous species. In this proof of concept study, we examined the effect of ATR exposure, at a supra-environmental dose (5 mg/kg bw/day), beginning on E9.5 in utero, prior to sexual differentiation of the reproductive tissues, until 26 weeks of age, on the development of the mouse penis. Notably, this is the first study to specifically investigate whether ATR can affect penis characteristics. We show that ATR exposure, beginning in utero, causes a shortening (demasculini..

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Grants

Awarded by University of Melbourne


Awarded by NIH


Awarded by NHMRC


Funding Acknowledgements

This work was supported by University of Melbourne internal funds [R06000010 to M.P.G.], as well as NIH R01DK096263 and NHMRC APP1098480 to A.J.P.