Journal article

Transition State Characteristics During Cell Differentiation

Rowan Brackston, Eszter Lakatos, Michael PH Stumpf

Published : 2018

Abstract

Abstract Models describing the process of stem-cell differentiation are plentiful, and may offer insights into the underlying mechanisms and experimentally observed behaviour. Waddington’s epigenetic landscape has been providing a conceptual framework for differentiation processes since its inception. It also allows, however, for detailed mathematical and quantitative analyses, as the landscape can, at least in principle, be related to mathematical models of dynamical systems. Here we focus on a set of dynamical systems features that are intimately linked to cell differentiation, by considering exemplar dynamical models that capture important aspects of stem cell differentiation dynamics. Th..

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University of Melbourne Researchers

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