Journal article

The application of human pluripotent stem cells to model the neuronal and glial components of neurodevelopmental disorders

KM Lee, ZH Hawi, HC Parkington, CL Parish, PV Kumar, JM Polo, MA Bellgrove, J Tong

MOLECULAR PSYCHIATRY | NATURE PUBLISHING GROUP | Published : 2020

Abstract

Cellular models of neurodevelopmental disorders provide a valuable experimental system to uncover disease mechanisms and novel therapeutic strategies. The ability of induced pluripotent stem cells (iPSCs) to generate diverse brain cell types offers great potential to model several neurodevelopmental disorders. Further patient-derived iPSCs have the unique genetic and molecular signature of the affected individuals, which allows researchers to address limitations of transgenic behavioural models, as well as generate hypothesis-driven models to study disorder-relevant phenotypes at a cellular level. In this article, we review the extant literature that has used iPSC-based modelling to understa..

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Grants

Awarded by National Health and Medical Research Council (NHMRC)


Awarded by Rebecca L Cooper Medical Research Foundation


Awarded by Monash University


Awarded by NHMRC


Funding Acknowledgements

We acknowledge the financial support of the National Health and Medical Research Council (NHMRC) [Early Career Fellowship ID 1112452 (JT)], the Society for Mental Health Research [Early Career Research Project Grant Award (JT)], the Rebecca L Cooper Medical Research Foundation [Medical Research Grant ID 10409 (JT)] and Monash University [Strategic Grant Scheme ID SGS16-0410 (JT)]. MAB is supported by a Senior Research Fellowship from the NHMRC (APP1154378). MAB, JT, and ZH are supported by project funding from the NHMRC (APP1146644).