Journal article
Natural Killer Cells Suppress T Cell-Associated Tumor Immune Evasion
AJ Freeman, SJ Vervoort, KM Ramsbottom, MJ Kelly, J Michie, L Pijpers, RW Johnstone, CJ Kearney, J Oliaro
Cell Reports | CELL PRESS | Published : 2019
Abstract
Freeman et al. use a series of genome-wide loss-of-function genetic screens to identify genes that limit tumor sensitivity to killing by natural killer cells. The findings highlight that natural killer cells can suppress tumor immune evasion from T cells, identifying a potential strategy to overcome resistance to checkpoint blockade therapy.
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Funding Acknowledgements
We acknowledge the Australian Cancer Research Foundation and the following Peter MacCallum Cancer Centre core research facilities: The Victorian Centre for Functional Genomics, Molecular Genomics, Flow Cytometry, and Bioinformatics and the Centre for Advanced Histology and Microscopy. We would like to acknowledge the TCGA Research Network and Magnus Zethoven for his assistance with TCGA analyses. A.J.F. was supported by scholarships from the Australian Commonwealth Government, Steer North Australia, and the Peter MacCallum Cancer Foundation. C.J.K. was supported by a National Health and Medical Research Council (NHMRC) Early Career Fellowship. J.O. was supported by NHMRC, National Breast Cancer Foundation, and Peter MacCallum Cancer Foundation project grants.