Journal article

Effect of angiotensin II receptor blocker and salt supplementation on short-term blood pressure variability in type 2 diabetes

Angela X Chen, John L Moran, Renata Libianto, Sara Baqar, Christopher O'Callaghan, Richard J MacIsaac, George Jerums, Elif Ekinci

Journal of Human Hypertension | NATURE PUBLISHING GROUP | Published : 2020

Abstract

High blood pressure variability (BPV) has been associated with increased cardiovascular (CV) risk. The effect of dietary salt and renin-angiotensin-aldosterone system (RAAS) activity on short-term BPV in type 2 diabetes mellitus (T2DM) is not well characterised. We aimed to determine the effect of dietary salt (sodium chloride, NaCl) supplementation on 24-h mean arterial BPV (24hBPV) during angiotensin II receptor blocker (telmisartan) use and to evaluate the effects of age, sex, plasma renin activity (PRA) and serum aldosterone on 24hBPV. In a randomised, double-blind, crossover study, patients with T2DM (n = 28), treated with telmisartan received NaCl (100 mmol/24 h) or placebo capsules du..

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Grants

Awarded by NHMRC Postgraduate Research Scholarship


Awarded by NHRMC Early Career Fellowship


Awarded by Heart Foundation Scholarship


Funding Acknowledgements

This work was supported by an NHMRC Postgraduate Research Scholarship (grant number APP466611 to EIE), NHRMC Early Career Fellowship (grant number APP1054312 to EIE) and Heart Foundation Scholarship (grant number 100287 to SB).