Journal article

Genetic literacy series: clinical application of pharmacogenetics for adverse reactions to antiepileptic drugs An ILAE Commission Review

Zhongbin Zhang, Ye Wu, Nigel CK Tan, Yuwu Jiang, Samuel F Berkovic, Helen Cross, Peter De Jonghe, Alica Goldman, Ingo Helbig, Mitsuhiro Kato, Daniel H Lowenstein, Heather C Mefford, Steven Petrou, Parthasathy Satishchandra

EPILEPTIC DISORDERS | JOHN LIBBEY EUROTEXT LTD | Published : 2019

Abstract

Adverse drug reactions are a leading cause of treatment failure with antiepileptic drugs. Adverse drug reactions are also a major source of morbidity and mortality, and a substantial burden on the use and costs of health care. Recent pharmacogenetic studies have shown that some adverse drug reactions are associated with genetic variants, which has changed how we select antiepileptic drugs for individual patients. This article, beginning with a case of an adverse drug reaction induced by carbamazepine, will answer four key questions about pharmacogenetics of adverse drug reactions: (1) What types of adverse drug reactions can be caused by antiepileptic drugs? (2) What is pharmacogenetics? (3)..

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