Journal article
TRAIL-Expressing Monocyte/Macrophages Are Critical for Reducing Inflammation and Atherosclerosis
SP Cartland, SW Genner, GJ Martínez, S Robertson, M Kockx, RC Lin, JF O'Sullivan, YC Koay, P Manuneedhi Cholan, MA Kebede, AJ Murphy, S Masters, MR Bennett, W Jessup, L Kritharides, C Geczy, S Patel, MM Kavurma
Iscience | CELL PRESS | Published : 2019
Abstract
Circulating tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)levels are reduced in patients with cardiovascular disease, and TRAIL gene deletion in mice exacerbates atherosclerosis and inflammation. How TRAIL protects against atherosclerosis and why levels are reduced in disease is unknown. Here, multiple strategies were used to identify the protective source of TRAIL and its mechanism(s)of action. Samples from patients with coronary artery disease and bone-marrow transplantation experiments in mice lacking TRAIL revealed monocytes/macrophages as the main protective source. Accordingly, deletion of TRAIL caused a more inflammatory macrophage with reduced migration, displa..
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Awarded by National Heart Foundation of Australia
Funding Acknowledgements
We would like to thank Professor Paul Pilowsky for reading the manuscript. This work was supported by a University of Sydney Early Career Research Grant (S.P.C.), a University of Sydney Sydney Medical School Foundation Fellowship (J.F.O.) a Heart Foundation of Australia Career Development Award (CR 12S 6833; M.M.K.) and a Perpetual IMPACT Philanthropy Grant (IPAP2018/1674; M.M.K. and S.P.C.).