Journal article

Management of locally recurrent nasopharyngeal carcinoma.

Anne WM Lee, Wai Tong Ng, Jimmy YW Chan, June Corry, Antti Mäkitie, William M Mendenhall, Alessandra Rinaldo, Juan P Rodrigo, Nabil F Saba, Primož Strojan, Carlos Suárez, Jan B Vermorken, Sue S Yom, Alfio Ferlito

Cancer Treat Rev | Published : 2019

Abstract

As a consequence of the current excellent loco-regional control rates attained using the generally accepted treatment paradigms involving intensity-modulated radiotherapy for nasopharyngeal carcinoma (NPC), only 10-20% of patients will suffer from local and/or nodal recurrence after primary treatment. Early detection of recurrence is important as localized recurrent disease is still potentially salvageable, but this treatment often incurs a high risk of major toxicities. Due to the possibility of radio-resistance of tumors which persist or recur despite adequate prior irradiation and the limited tolerance of adjacent normal tissues to sustain further additional treatment, the management of l..

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University of Melbourne Researchers