Journal article

Late-onset hypogonadism: metabolic impact

M Grossmann, M Ng Tang Fui, AS Cheung

Andrology | WILEY | Published : 2020

Abstract

BACKGROUND: Obesity and dysglycemia (comprising insulin resistance, the metabolic syndrome and type 2 diabetes), that is diabesity, are associated with reduced circulating testosterone and, in some men, clinical features consistent with androgen deficiency. OBJECTIVE: To review the metabolic impact of late-onset hypogonadism. METHODS: Comprehensive literature search with emphasis on recent publications. RESULTS: Obesity is one of the strongest modifiable risk factors for late-onset hypogonadism, and coexisting diabetes leads to further hypothalamic-pituitary-testicular axis suppression. The hypothalamic-pituitary-testicular axis suppression is functional and hence potentially reversible, and..

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