Journal article

Characterising the structure of cognitive heterogeneity in schizophrenia spectrum disorders. A systematic review and narrative synthesis

Sean P Carruthers, Tamsyn E Van Rheenen, Caroline Gurvich, Philip J Sumner, Susan L Rossell

Neuroscience & Biobehavioral Reviews | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2019


The aim of the present review was to systematically summarise our current understanding of the structure of the cognitive heterogeneity that exists within schizophrenia spectrum disorder (SSD). Fifty-two relevant studies were identified from January 1980 to March 2019 that investigated cognitive subgroups within SSD. Twenty-five studies employed classification criteria based on current neuropsychological function, 14 studies employed various data-driven subgrouping methodologies and 13 studies investigated putative cognitive symptom trajectories. Despite considerable methodological variability, three distinct cognitive subgroups reliability emerged; a relatively intact cognitive subgroup cha..

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University of Melbourne Researchers