Characterising the structure of cognitive heterogeneity in schizophrenia spectrum disorders. A systematic review and narrative synthesis
Sean P Carruthers, Tamsyn E Van Rheenen, Caroline Gurvich, Philip J Sumner, Susan L Rossell
Neuroscience & Biobehavioral Reviews | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2019
The aim of the present review was to systematically summarise our current understanding of the structure of the cognitive heterogeneity that exists within schizophrenia spectrum disorder (SSD). Fifty-two relevant studies were identified from January 1980 to March 2019 that investigated cognitive subgroups within SSD. Twenty-five studies employed classification criteria based on current neuropsychological function, 14 studies employed various data-driven subgrouping methodologies and 13 studies investigated putative cognitive symptom trajectories. Despite considerable methodological variability, three distinct cognitive subgroups reliability emerged; a relatively intact cognitive subgroup cha..View full abstract
Awarded by Australian National Health and Medical Research Council (NHMRC)
This work was supported by Australian Postgraduate Awards (S.P.C, P.J.S) and by the Australian National Health and Medical Research Council (NHMRC; fellowships to S.L.R (ID 1154651), C.G (ID: 5467262), T.V.R (1088785) and a project grant to S.L.R (ID: 1060664)).