Journal article
Genetic resilience to Alzheimer's disease in APOE ε4 homozygotes: A systematic review
AJ Huq, P Fransquet, SM Laws, J Ryan, R Sebra, CL Masters, IM Winship, PA James, P Lacaze
Alzheimer S and Dementia | WILEY | Published : 2019
Abstract
Introduction: Individuals with homozygosity for the apolipoprotein E (APOE) ε4 allele are in the highest risk category for late-onset Alzheimer's disease (LOAD). However, some individuals in this category do not develop LOAD beyond the age of 75 years, despite being at elevated genetic risk. These “resilient” individuals may carry protective genetic factors. Methods: This study aimed to systematically review any previous studies that involved resilient APOE ε4 homozygotes and to identify possible modifying or protective genetic factors. Results: Fifteen studies met our inclusion criteria and reported genetic factors contributing to reduced risk. We found that only two single nucleotide polym..
View full abstractGrants
Awarded by University of Melbourne
Funding Acknowledgements
Dr. Huq is supported by an Australian Government Research Training Program Scholarship (University of Melbourne reference number 96756) and the Yulgilbar Alzheimer Research Program.