Using pneumococcal carriage studies to monitor vaccine impact in low- and middle-income countries
Jocelyn Chan, Cattram D Nguyen, Eileen M Dunne, E Kim Mulholland, Tuya Mungun, William S Pomat, Eric Rafai, Catherine Satzke, Daniel M Weinberger, Fiona M Russell
Vaccine | ELSEVIER SCI LTD | Published : 2019
Pneumococcal disease is a leading cause of childhood mortality, globally. The pneumococcal conjugate vaccine (PCV) has been introduced to many countries worldwide. However there are few studies evaluating PCV impacts in low- and middle-income countries (LMIC) because measuring the impact of PCV on pneumococcal disease in LMICs is challenging. We review the role of pneumococcal carriage studies for the evaluation of PCVs in LMICs and discuss optimal methods for conducting these studies. Fifteen carriage studies from 13 LMICs quantified the effects of PCV on carriage, and identified replacement carriage serotypes in the post-PCV era. Ten studies reported on the indirect effects of PCV on carri..View full abstract
Thank you to Claire von Mollendorf for providing an advance copy of a submitted manuscript for this review. FMR and CS are supported by National Health and Medical Research Council fellowships. JC is supported by scholarships from Yale University (Fox Fellowship) and the Australian Government.