Reference values for 30 common biochemistry analytes across 5 different analyzers in neonates and children 30 days to 18 years of age

Abstract

BACKGROUND: Age-specific reference intervals (RIs) have been developed for biochemistry analytes in children. However, the ability to interpret results from multiple laboratories for 1 individual is limited. This study reports a head-to-head comparison of reference values and agespecific RIs for 30 biochemistry analytes for children across 5 analyzer types. METHODS: Blood was collected from healthy newborns and children 30 days to<18 years of age. Serum aliquots from the same individual were analyzed on 5 analyzer types. Differences in the mean reference values of the analytes by the analyzer types were investigated using mixed-effect regression analysis and by comparing maximum variation be..