Malaria vaccine candidates displayed on novel virus-like particles are immunogenic and induce transmission-blocking activity
Jo-Anne Chan, David Wetzel, Linda Reiling, Kazutoyo Miura, Damien R Drew, Paul R Gilson, David A Anderson, Jack S Richards, Carole A Long, Manfred Suckow, Volker Jenzelewski, Takafumi Tsuboi, Michelle J Boyle, Michael Piontek, James G Beeson
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2019
The development of effective malaria vaccines remains a global health priority. Currently, the most advanced vaccine, known as RTS,S, has only shown modest efficacy in clinical trials. Thus, the development of more efficacious vaccines by improving the formulation of RTS,S for increased efficacy or to interrupt malaria transmission are urgently needed. The RTS,S vaccine is based on the presentation of a fragment of the sporozoite antigen on the surface of virus-like particles (VLPs) based on human hepatitis B virus (HBV). In this study, we have developed and evaluated a novel VLP platform based on duck HBV (known as Metavax) for malaria vaccine development. This platform can incorporate larg..View full abstract
Funding was provided by PATH Malaria Vaccine Initiative and the National Health and Medical Research Council (NHMRC) of Australia (Senior Research Fellowship and Program Grant to JB, Career Development Fellowship to MB). Burnet Institute is supported by funding from the NHMRC Independent Research Institutes Infrastructure Support Scheme and a Victorian State Government Operational Infrastructure grant. The SMFA work performed here was supported was supported in part by the intramural program of the National Institute of Allergy and Infectious Diseases/NIH. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. ARTES Biotechnology GmbH provided support in the form of salaries for authors (DW, MS, VJ and MP) and generation of VLPs, but did not have any additional role in the study design, data collection and analysis, decision to publish or preparation of the manuscript. The specific roles of these authors are articulated in the 'Author Contributions' section.