Journal article

High-quality Schistosoma haematobium genome achieved by single-molecule and long-range sequencing

Andreas J Stroehlein, Pasi K Korhonen, Teik Min Chong, Yan Lue Lim, Kok Gan Chan, Bonnie Webster, David Rollinson, Paul J Brindley, Robin B Gasser, Neil D Young

GigaScience | OXFORD UNIV PRESS | Published : 2019

Abstract

BACKGROUND: Schistosoma haematobium causes urogenital schistosomiasis, a neglected tropical disease affecting >100 million people worldwide. Chronic infection with this parasitic trematode can lead to urogenital conditions including female genital schistosomiasis and bladder cancer. At the molecular level, little is known about this blood fluke and the pathogenesis of the disease that it causes. To support molecular studies of this carcinogenic worm, we reported a draft genome for S. haematobium in 2012. Although a useful resource, its utility has been somewhat limited by its fragmentation. FINDINGS: Here, we systematically enhanced the draft genome of S. haematobium using a single-molecule ..

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Grants

Awarded by National Cancer Institute, National Institutes of Health, USA


Funding Acknowledgements

Support from the National Health and Medical Research Council (NHMRC) of Australia, the Australian Research Council and MelbourneWater Corporation, The University ofMelbourne (BIP) (R.B.G.), and the National Cancer Institute, National Institutes of Health, USA (award R01CA164719) (P.J.B.) is gratefully acknowledged. P.K.K. holds an NHMRC Early Career Research Fellowship. N.D.Y. holds an NHMRC Career Development Fellowship.