Effects of Bovine Serum Albumin and High pH Pre-Treatment on the Remineralisation of Enamel Subsurface Lesions in vitro
James R Fernando, Peiyan Shen, Glenn D Walker, Yi Yuan, David P Stanton, Coralie Reynolds, Eric C Reynolds
CARIES RESEARCH | KARGER | Published : 2020
Accumulated intra-lesion protein such as serum albumin has been speculated to impede remineralisation of carious enamel lesions. The aim of this study was to assess whether intra-lesion bovine serum albumin (BSA) affected subsequent remineralisation of enamel subsurface lesions. Confocal microscopy was used to confirm localisation of BSA in artificial enamel subsurface lesions and its subsequent degradation by a high pH sodium hypochlorite treatment. An in vitro remineralisation experiment tested the effect of intra-lesion BSA, and its degradation by sodium hypochlorite, on remineralisation of subsurface lesions by casein phosphopeptide stabilised amorphous calcium fluoride phosphate. In add..View full abstract
This study was supported by the Australian Government, Department of Industry, Innovation and Science. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.