Journal article
Glucocorticoid for Hearing Preservation After Cochlear Implantation: A Systemic Review and Meta-analysis of Animal Studies
Chanan Shaul, Padmavathi K Venkatagiri, Jonathon Lo, Hayden T Eastwood, Christofer W Bester, Robert JS Briggs, Stephen J O'Leary
OTOLOGY & NEUROTOLOGY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2019
Abstract
OBJECTIVES: To conduct systematic review and meta-analyses of preclinical studies describing the efficacy of glucocorticoids administered via different routes for hearing preservation after cochlear implantation. DATA SOURCES: A literature search was performed in PubMed to identify peer-reviewed articles published before December 31, 2017, with no language restrictions. Search components were "Cochlear implant," "Glucocorticoids," and "Hearing preservation." The results were specified for animal studies. STUDY SELECTION: Original studies in which glucocorticoids were administered before or during cochlear implantation in animal models and hearing threshold shifts were measured using auditory..
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Funding Acknowledgements
C.S. is supported by the Royal Victorian Eye and Ear Hospital, and the Gordon Darling Bequest to the University of Melbourne. S.J.O. is supported by a Practitioner Fellowship from the National Health and Medical Research Foundation (Australia).