Glucocorticoid for Hearing Preservation After Cochlear Implantation: A Systemic Review and Meta-analysis of Animal Studies
Chanan Shaul, Padmavathi K Venkatagiri, Jonathon Lo, Hayden T Eastwood, Christofer W Bester, Robert JS Briggs, Stephen J O'Leary
Otology & Neurotology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2019
OBJECTIVES: To conduct systematic review and meta-analyses of preclinical studies describing the efficacy of glucocorticoids administered via different routes for hearing preservation after cochlear implantation. DATA SOURCES: A literature search was performed in PubMed to identify peer-reviewed articles published before December 31, 2017, with no language restrictions. Search components were "Cochlear implant," "Glucocorticoids," and "Hearing preservation." The results were specified for animal studies. STUDY SELECTION: Original studies in which glucocorticoids were administered before or during cochlear implantation in animal models and hearing threshold shifts were measured using auditory..View full abstract
C.S. is supported by the Royal Victorian Eye and Ear Hospital, and the Gordon Darling Bequest to the University of Melbourne. S.J.O. is supported by a Practitioner Fellowship from the National Health and Medical Research Foundation (Australia).