Journal article

Blood cytokine, chemokine and growth factor profiling in a cohort of pregnant women from tropical countries

Carlota Dobano, Azucena Bardaji, Swati Kochar, Sanjay K Kochar, Norma Padilla, Marta Lopez, Holger W Unger, Maria Ome-Kaius, Maria Eugenia Castellanos, Myriam Arevalo-Herrera, Dhiraj Hans, Flor E Martinez-Espinosa, Camila Botto-Menezes, Adriana Malheiros, Meghna Desai, Aina Casellas, Chetan E Chitnis, Stephen Rogerson, Ivo Mueller, Clara Menendez Show all

Cytokine | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2020

Abstract

The immune status of women changes during and after pregnancy, differs between blood compartments at delivery and is affected by environmental factors particularly in tropical areas endemic for multiple infections. We quantified the plasma concentration of a set of thirty-one TH1, TH2, TH17 and regulatory cytokines, pro-inflammatory and anti-inflammatory cytokines and chemokines, and growth factors (altogether biomarkers), in a cohort of 540 pregnant women from five malaria-endemic tropical countries. Samples were collected at recruitment (first antenatal visit), delivery (periphery, cord and placenta) and postpartum, allowing a longitudinal analysis. We found the lowest concentration of bio..

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Grants

Awarded by European Union


Awarded by Ministerio de Economia y Competitividad (National R&D Internationalization Programme, EUROSALUD 2008, Spain)


Awarded by Malaria in Pregnancy Consortium (MiPc) through Bill & Melinda Gates Foundation


Awarded by Ministerio de Economia y Competitividad


Awarded by National Health and Medical Research Council Senior Research Fellowship


Funding Acknowledgements

The PREGVAX project received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement 201588, and co-funding from the Ministerio de Economia y Competitividad (National R&D Internationalization Programme, EUROSALUD 2008, Spain) under grant agreement EUS2009-03560. The Latin American sites received co-funding from the Centers for Disease Control and Prevention (CDC) Foundation, which received a grant from the Malaria in Pregnancy Consortium (MiPc) which is partially funded through a grant from the Bill & Melinda Gates Foundation to the Liverpool School of Tropical Medicine (46099). The studies in PNG also received co-funding from the MiPc. CD was supported by a fellowship from the Ministerio de Economia y Competitividad (RYC2008-02631) and was affiliate of the EU FP7 Network of Excellence EviMalaR, and IM was supported by a National Health and Medical Research Council Senior Research Fellowship (GNT1043345). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. ISGlobal is a member of the CERCA Program, Generalitat de Catalunya.