Journal article

The perioperative administration of dexamethasone and infection (PADDI) trial protocol: rationale and design of a pragmatic multicentre non-inferiority study

Tomas B Corcoran, Paul S Myles, Andrew B Forbes, Ed O'Loughlin, Kate Leslie, David Story, Timothy G Short, Matthew TV Chan, Pauline Coutts, Jaspreet Sidhu, Allen C Cheng, Leon A Bach, Kwok M Ho

BMJ OPEN | BMJ PUBLISHING GROUP | Published : 2019

Abstract

INTRODUCTION: The intraoperative administration of dexamethasone for prophylaxis against postoperative nausea and vomiting is a common and recommended practice. The safety of the administration of this immunosuppressive agent at a time of significant immunological disruption has not been rigorously evaluated in terms of infective complications. METHODS/ANALYSIS: This is a pragmatic, multicentre, randomised, controlled, non-inferiority trial. A total of 8880 patients undergoing elective major surgery will be enrolled. Participants will be randomly allocated to receive either dexamethasone 8 mg or placebo intravenously following the induction of anaesthesia in a 1:1 ratio, stratified by centre..

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