Circuit Hemodynamics and Circuit Failure during Continuous Renal Replacement Therapy

Abstract

Objectives: To study hemodynamic changes within continuous renal replacement therapy circuits and evaluate their relationship with continuous renal replacement therapy longevity. Design: Analysis of downloaded variables recorded by continuous renal replacement therapy machines during multiple episodes of clinical care. Setting: Tertiary ICU in Melbourne, Australia. Patients: Cohort of 149 ICU patients: 428 episodes of continuous renal replacement therapy. Interventions: None. Measurements and Main Results: Indices of continuous renal replacement therapy function representing 554,991 minutes were assessed including blood flow, access pressure, effluent pressure, prefilter pressure, and return..