Journal article

Isomers of per- and polyfluoroalkyl substances and uric acid in adults: Isomers of C8 Health Project in China

Xiao-Wen Zeng, Caroline J Lodge, Shyamali C Dharmage, Michael S Bloom, Yunjiang Yu, Mo Yang, Chu Chu, Qing-Qing Li, Li-Wen Hu, Kang-Kang Liu, Bo-Yi Yang, Guang-Hui Dong

Environment International | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2019

Abstract

BACKGROUND: Greater levels of serum per- and polyfluoroalkyl substances (PFAS) are known to be associated with higher uric acid which itself leads to a number of chronic diseases. However, whether this association varies across PFAS isomers which recently have been found to be associated with human health remains unknown. OBJECTIVES: To address this research gap, we explored isomer-specific associations between serum PFAS and uric acid in Chinese adults. METHODS: We conducted a cross-sectional study of associations between serum PFAS isomer and serum uric acid in 1612 participants from the Isomer of C8 Health Project. We used multivariable linear and logistic regression models to analyze ser..

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Grants

Awarded by National Natural Science Foundation of China


Awarded by National Key Research and Development Program of China


Awarded by Natural Science Foundation of Guangdong Province


Awarded by State Key Laboratory of Organic Geochemistry GIGCAS


Funding Acknowledgements

This study was funded by grants from the National Natural Science Foundation of China (No. 81673127), the National Key Research and Development Program of China (No. 2018YFE0106900, No. 2016YFC0207000), the Natural Science Foundation of Guangdong Province (No. 2016A030313342), the State Key Laboratory of Organic Geochemistry GIGCAS (No. SKLOG-201608). The above funding has not taken control of the study design. We are grateful to all participants involving this project. The views expressed in this manuscript belong to the authors only.