Journal article

A loss of estrogen signaling in the aromatase deficient mouse penis results in mild hypospadias

Samuel M Cripps, Deidre M Mattiske, Jay R Black, Gail P Risbridger, Luke C Govers, Tiffany R Phillips, Andrew J Pask

Differentiation | ELSEVIER SCI LTD | Published : 2019

Abstract

Hypospadias is the abnormal opening of the urethra on the underside of the penis and occurs in approximately 1/125 live male births worldwide. The incidence rate of hypospadias has dramatically increased over the past few decades. This is now attributed, at least in part, to our exposure to endocrine-disrupting chemicals (EDCs) which alter the hormonal signals required for development of the penis. In humans androgens are the main drivers of fusion of the urethral folds to form the urethra within the shaft of the penis, a process required for termination of the urethra in its normal location at the tip of the penis. However, recent research has suggested that estrogen also plays a role in th..

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Grants

Awarded by U.S. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Grant


Awarded by National Health and Medical Research Council of Australia


Funding Acknowledgements

The authors acknowledge technical support by the Melbourne Trace Analysis for Chemical, Earth and Environmental Sciences (TrACEES) Platform for access to the GE Phoenix Nanotom M Micro-CT instrument. Research reported in this publication was supported by the U.S. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Grant R01DK096263 (to A.J.P.), and by the National Health and Medical Research Council of Australia Project Grant APP1098480 (to G.P.R. and A.J.P.).