Journal article

Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer's disease

Xavier Hadoux, Flora Hui, Jeremiah KH Lim, Colin L Masters, Alice Pebay, Sophie Chevalier, Jason Ha, Samantha Loi, Christopher J Fowler, Christopher Rowe, Victor L Villemagne, Edward N Taylor, Christopher Fluke, Jean-Paul Soucy, Frederic Lesage, Jean-Philippe Sylvestre, Pedro Rosa-Neto, Sulantha Mathotaarachchi, Serge Gauthier, Ziad S Nasreddine Show all

NATURE COMMUNICATIONS | NATURE PUBLISHING GROUP | Published : 2019

Abstract

Studies of rodent models of Alzheimer's disease (AD) and of human tissues suggest that the retinal changes that occur in AD, including the accumulation of amyloid beta (Aβ), may serve as surrogate markers of brain Aβ levels. As Aβ has a wavelength-dependent effect on light scatter, we investigate the potential for in vivo retinal hyperspectral imaging to serve as a biomarker of brain Aβ. Significant differences in the retinal reflectance spectra are found between individuals with high Aβ burden on brain PET imaging and mild cognitive impairment (n = 15), and age-matched PET-negative controls (n = 20). Retinal imaging scores are correlated with brain Aβ loads. The findings are validated in an..

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Grants

Awarded by Sylvia and Charles Viertel Charitable Foundation


Awarded by Australian Research Council Centre of Excellence for Gravitational Wave Discovery (OzGrav)


Funding Acknowledgements

We thank Mr Baillieu Myer and Mrs Samantha Baillieu for supporting this work. We also thank Dr Qiao-xin Li and Dr Holly Chinnery for their help with immunohistochemistry of mouse retinal sections. We appreciate the administrative assistance provided by Cheryl Donohue, Vasantha Pather Lowen and Vikki Marshall. We are grateful to investigators and staff affiliated with the Australian Imaging, Biomarker and Lifestyle Study of Ageing for assistance with study participant recruitment and for the provision of PET scan and clinical data. We are grateful for the generous support received from the Yulgilbar Alzheimer's Research Program, Pratt Foundation, Joan Margaret Ponting Charitable Trust, Hecht Charitable Trust (Perpetual), Coopers Brewery Foundation, Eldon & Anne Foote Donor Advised Fund and The Sylvia and Charles Viertel Charitable Foundation (VTL2015CO18; PvW was the recipient of a Clinical Investigatorship). PvW was the recipient of a University of Melbourne Annemarie Mankiewicz-Zelkin Fellowship. C.F. receives support from the Australian Research Council Centre of Excellence for Gravitational Wave Discovery (OzGrav; project number CE170100004). CERA receives Operational Infrastructure Support from the Victorian Government. The CQDM/Brain Canada Focus on Brain grant and the BLN-CE program, provided support for the Montreal cohort.