Journal article

PSEN1 Delta E9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia

Henna Konttinen, Mauricio E Castro Cabral-da-Silva, Sohvi Ohtonen, Sara Wojciechowski, Anastasia Shakirzyanova, Simone Caligola, Rosalba Giugno, Yevheniia Ishchenko, Damian Hernandez, Mohammad Feroze Fazaludeen, Shaila Eamen, Mireia Gomez Budia, Ilkka Fagerlund, Flavia Scoyni, Paula Korhonen, Nadine Huber, Annakaisa Haapasalo, Alex W Hewitt, James Vickers, Grady C Smith Show all

Stem Cell Reports | CELL PRESS | Published : 2019

Grants

Awarded by Academy of Finland


Awarded by European Union's Horizon 2020 research and innovation program


Awarded by Yrjo Jahnsson's Foundation


Awarded by National Health and Medical Research Council of Australia (NHMRC)


Awarded by NHMRC Boosting Dementia Research Leadership Fellowship


Awarded by National Health and Medical Research Council


Awarded by Australian Research Council Future Fellowship


Funding Acknowledgements

This work is part of an EU Joint Program -Neurodegenerative Disease Research (JPND) project. This study was funded by the University of Eastern Finland, the Academy of Finland under grant nos. 301234, 298071, 305516, and 315459 (FiNeFTD), the European Union's Horizon 2020 research and innovation program under grant agreement no. 643417, Finnish Instrumentarium Science Foundation, and Yrjo Jahnsson's Foundation grant no. 20187070, the National Health and Medical Research Council of Australia (NHMRC, APP1125796), an NHMRC Boosting Dementia Research Leadership Fellowship (APP1135720), Yulgilbar Alzheimer's Research Program, the DHB Foundation, the C.F. Leung Memorial Trust, the Brain Foundation, Dementia Australia, a National Health and Medical Research Council Practitioner Fellowship (AWH) and Senior Research Fellowship (AP, 1154389), an Australian Research Council Future Fellowship (AP, FT140100047), the University of Melbourne and Operational Infrastructure Support from the Victorian Government. We thank Matti Viitala for skin biopsies, Louise A. Rooney, Sophie Chevalier, and Maciej Daniszewski for the characterization of iPSC lines, Vikrant Singh for virtual karyotype help, and Helena H. Liang for culture of biopsies to fibroblasts. We also thank Finnish Functional Genomics Center (FFGC), University of Turku and Abo Akademi and Biocenter Finland, for RNA sequencing. This work was carried out with the support of UEF Cell and Tissue Imaging Unit, University of Eastern Finland.