Journal article

Electrical impedance tomography identifies a distinct change in regional phase angle delay pattern in ventilation filling immediately prior to a spontaneous pneumothorax

Martijn Miedema, Andy Adler, Karen E McCall, Elizabeth J Perkins, Anton H van Kaam, David G Tingay

Journal of Applied Physiology | AMER PHYSIOLOGICAL SOC | Published : 2019

Abstract

Pneumothoraxes are common in preterm infants and are a major cause of morbidity. Early detection and treatment of pneumothoraxes are vital to minimize further respiratory compromise. Electrical impedance tomography (EIT) has been suggested as a method of rapidly detecting pneumothoraxes at the bedside. Our objective was to define the EIT-derived regional phase angle differences in filling characteristics before and during spontaneous pneumothoraxes in preterm lambs. Preterm lambs (124-127-day gestation) were ventilated with high-frequency oscillatory ventilation for 120 min. EIT data and cardiorespiratory parameters were monitored continuously and recorded for 3 min every 15 min. Six animals..

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Grants

Awarded by National Health and Medical Research Council (Canberra, ACT, Australia)


Awarded by National Health and Medical Research Council


Funding Acknowledgements

This study is supported by National Health and Medical Research Council Project Grant 1009287 (Canberra, ACT, Australia) and the Victorian Government Operational Infrastructure Support Program (Melbourne, VIC, Australia). D. G. Tingay is supported by a National Health and Medical Research Council Clinical Career Development Fellowship (Grant 1053889). All EIT hardware and software used in this study were purchased by the Murdoch Children's Research Institute or are available as open-source software.