Conference Proceedings
Fine-mapping of common genetic variants associated with colorectal tumor risk identified potential functional variants
Mengmeng Du, Shuo Jiao, Stephanie A Rosse, Manish Gala, Goncalo Abecasis, Stephane Bezieau, Hermann Brenner, Graham Casey, Jenny Chang-Claude, Steven Gallinger, Thomas J Hudson, Sebastien Kuery, Loic L Marchand, Suzanne M Leal, Polly A Newcomb, Deborah A Nickerson, John D Potter, Martha L Slattery, Li Hsu, Andrew T Chan Show all
CANCER RESEARCH | AMER ASSOC CANCER RESEARCH | Published : 2014
Abstract
Abstract Background: Genome-wide association studies (GWAS) have identified many common single nucleotide polymorphisms (SNPs) associated with colorectal cancer risk. These SNPs may tag correlated variants with biological importance. Fine-mapping around GWAS loci facilitates detection of functional candidates and additional independent risk variants. Methods: We analyzed 11,900 cases and 14,311 controls in the Genetics and Epidemiology of Colorectal Cancer Consortium and the Colon Cancer Family Registry. To fine-map genomic regions containing all known common risk variants, we imputed high-density genetic data from the 1000 Genomes Project. We tested association..
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