Journal article

Neurocognitive heterogeneity in young offspring of patients with bipolar disorder: The effect of putative clinical stages

Emre Bora, Gunes Can, Aysegul Ildiz, Gozde Ulas, Ceren Hidiroglu Ongun, Neslihan Emiroglu Inal, Aysegul Ozerdem

JOURNAL OF AFFECTIVE DISORDERS | ELSEVIER | Published : 2019

Abstract

BACKGROUND: Bipolar disorder (BD) is associated with significant cognitive heterogeneity. In recent years, a number of studies have investigated cognitive subgroups in BD using data-driven methods and found that BD includes several subgroups including a severely impaired and a neurocognitively intact cluster. Studies in offspring of BD (BDoff) are particularly important to establish the timing of emergence of cognitive subgroups but studies investigating cognitive heterogeneity in BDoff are lacking. Our aim was to investigate cognitive heterogeneity in BDoff and the relationship between cognitive heterogeneity and putative clinical stages of BD. METHODS: Seventy-one euthymic BDoff and 50 hea..

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University of Melbourne Researchers