Involvement of brain-derived neurotrophic factor (BDNF) in the long-term memory effects of glucocorticoid stimulation during adolescence/young adulthood
Maarten van den Buuse, Laetitia Buret, Rachel Hill
Behavioural Brain Research | ELSEVIER | Published : 2020
Brain-derived neurotrophic factor (BDNF) has been implicated in cognition and the effects of chronic stress. We have previously shown in mice that chronic adolescent treatment with corticosterone (CORT), to simulate stress, resulted in spatial memory deficits and markedly elevated levels of the N-methyl-D-aspartate (NMDA) receptor subunit NR2B in adult male BDNF heterozygous mice (BDNF+/-), but not in wildtype controls (WT) or females. The aim of the present study was to further characterize this 'two hit' model, including whether these effects are long-lasting. CORT treatment was delivered in the drinking water from 6 to 9 weeks of age. As previously demonstrated, male BDNF+/- mice treated ..View full abstract
This study was supported by a project grant from the National Health and Medical Research Council of Australia (NHMRC). MvdB was supported by a Senior Research Fellowship from the NHMRC. RH was supported by an Early Career Fellowship from the NHMRC and more recently by a Career Development Award. This funding source had no input in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article for publication.