Journal article
A Pilot, Double-Blind, Randomized, Controlled Trial of High-Dose Intravenous Vitamin C for Vasoplegia After Cardiac Surgery
F Yanase, L Bitker, L Hessels, E Osawa, T Naorungroj, SL Cutuli, PJ Young, J Ritzema, G Hill, C Latimer-Bell, A Hunt, GM Eastwood, A Hilton, R Bellomo
Journal of Cardiothoracic and Vascular Anesthesia | W B SAUNDERS CO-ELSEVIER INC | Published : 2020
Abstract
Objective: To conduct a pilot feasibility and physiologic efficacy study of high-dose vitamin C in patients with vasoplegia after cardiac surgery. Design: Prospective, double-blind, randomized, controlled trial. Setting: Two tertiary intensive care units (ICUs). Participants: Post-cardiac surgery patients with vasoplegia. Interventions: The authors randomly assigned the patients to receive either high-dose intravenous vitamin C (1,500 mg every 6 hours) or placebo. The primary outcome was time from randomization to resolution of vasoplegia. Secondary outcomes included total norepinephrine equivalent dose in the first 2 days, ICU length of stay, ICU mortality, and in-hospital mortality. Measur..
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Funding Acknowledgements
The trial received unrestricted funding support from the Anesthesia Intensive Care Trust Fund and a research grant from the Austin Medical Research Fund. Both funders were not involved in the design, conduct, analysis, and reporting of this study.