Journal article

Pilot, Double-Blind, Randomized, Controlled Trial of High-Dose Intravenous Vitamin C for Vasoplegia After Cardiac Surgery

Fumitaka Yanase, Laurent Bitker, Lara Hessels, Eduardo Osawa, Thummaporn Naorungroj, Salvatore L Cutuli, Paul J Young, Jay Ritzema, Georgia Hill, Charlotte Latimer-Bell, Anna Hunt, Glenn M Eastwood, Andrew Hilton, Rinaldo Bellomo

Journal of Cardiothoracic and Vascular Anesthesia | W B SAUNDERS CO-ELSEVIER INC | Published : 2020


OBJECTIVE: To conduct a pilot feasibility and physiologic efficacy study of high-dose vitamin C in patients with vasoplegia after cardiac surgery. DESIGN: Prospective, double-blind, randomized, controlled trial. SETTING: Two tertiary intensive care units (ICUs). PARTICIPANTS: Post-cardiac surgery patients with vasoplegia. INTERVENTIONS: The authors randomly assigned the patients to receive either high-dose intravenous vitamin C (1,500 mg every 6 hours) or placebo. The primary outcome was time from randomization to resolution of vasoplegia. Secondary outcomes included total norepinephrine equivalent dose in the first 2 days, ICU length of stay, ICU mortality, and in-hospital mortality. MEASUR..

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