Journal article

Biocompatible and Biodegradable Magnesium Oxide Nanoparticles with In Vitro Photostable Near-Infrared Emission: Short-Term Fluorescent Markers

Snjezana Tomljenovic-Hanic, Asma Khalid, Romina NORELLO, Amanda Abraham, Jean-Philippe Tetienne 1, Timothy Karle, Edward Lui, Kenong Xia, Tran Phong, Andrea J O'Connor

Nanomaterials | MDPI AG | Published : 2019

Abstract

Imaging of biological matter by using fluorescent nanoparticles (NPs) is becoming a widespread method for in vitro imaging. However, currently there is no fluorescent NP that satisfies all necessary criteria for short-term in vivo imaging: biocompatibility, biodegradability, photostability, suitable wavelengths of absorbance and fluorescence that differ from tissue auto-fluorescence, and near infrared (NIR) emission. In this paper, we report on the photoluminescent properties of magnesium oxide (MgO) NPs that meet all these criteria. The optical defects, attributed to vanadium and chromium ion substitutional defects, emitting in the NIR, are observed at room temperature in NPs of commercial ..

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Grants

Awarded by Australian Research Council


Awarded by ARC Australian Research Fellowship


Funding Acknowledgements

This work was partly supported with the assistance of the Australian Research Council under Discovery Project Scheme no. DP1096288, University of Melbourne Interdisciplinary Seed Grant, by an award under the Merit Allocation Scheme on the National Facility of the National Computational Infrastructure. S.T.-H. acknowledges an ARC Australian Research Fellowship (DP1096288).