Journal article

Biocompatible and Biodegradable Magnesium Oxide Nanoparticles with In Vitro Photostable Near-Infrared Emission: Short-Term Fluorescent Markers

Asma Khalid, Romina Norello, Amanda N Abraham, Jean-Philippe Tetienne, Timothy J Karle, Edward WC Lui, Kenong Xia, Phong A Tran, Andrea J O'Connor, Bruce G Mann, Richard de Boer, Yanling He, Alan Man Ching Ng, Aleksandra B Djurisic, Ravi Shukla, Snjezana Tomljenovic-Hanic

NANOMATERIALS | MDPI | Published : 2019


Imaging of biological matter by using fluorescent nanoparticles (NPs) is becoming a widespread method for in vitro imaging. However, currently there is no fluorescent NP that satisfies all necessary criteria for short-term in vivo imaging: biocompatibility, biodegradability, photostability, suitable wavelengths of absorbance and fluorescence that differ from tissue auto-fluorescence, and near infrared (NIR) emission. In this paper, we report on the photoluminescent properties of magnesium oxide (MgO) NPs that meet all these criteria. The optical defects, attributed to vanadium and chromium ion substitutional defects, emitting in the NIR, are observed at room temperature in NPs of commercial ..

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Awarded by Australian Research Council

Awarded by ARC Australian Research Fellowship

Funding Acknowledgements

This work was partly supported with the assistance of the Australian Research Council under Discovery Project Scheme no. DP1096288, University of Melbourne Interdisciplinary Seed Grant, by an award under the Merit Allocation Scheme on the National Facility of the National Computational Infrastructure. S.T.-H. acknowledges an ARC Australian Research Fellowship (DP1096288).