Journal article

Post-Exertional Malaise Is Associated with Hypermetabolism, Hypoacetylation and Purine Metabolism Deregulation in ME/CFS Cases

Neil R McGregor, Christopher W Armstrong, Donald P Lewis, Paul R Gooley

DIAGNOSTICS | MDPI | Published : 2019


Post-exertional malaise (PEM) is a cardinal predictive symptom in the definition of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). If the cases overexert themselves they have what is termed "payback" resulting in a worsening of symptoms or relapse which can last for days, weeks or even months. The aim was to assess the changes in biochemistry associated with the cases self-reported PEM scores over a 7-day period and the frequency of reporting over a 12-month period. Forty-seven ME/CFS cases and age/sex-matched controls had a clinical examination, completed questionnaires; were subjected to standard serum biochemistry; had their serum and urine metabolomes analyzed in an observa..

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Awarded by Judith Jane Mason and Harold Stannett Williams memorial foundation (Mason Foundation)

Funding Acknowledgements

This research was funded by the Judith Jane Mason and Harold Stannett Williams memorial foundation (The Mason Foundation) (MAS2017F046 in addition to funding without reference numbers in 2009, 2010, 2012 and 2015), philanthropic donations by Mr Douglas Stutt, the Field family and the Blake Beckett trust, and equipment grants from the Rowen White Foundation and the State of Victoria.