Journal article
Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis
MT Moutaoufik, R Malty, S Amin, Q Zhang, S Phanse, A Gagarinova, M Zilocchi, L Hoell, Z Minic, M Gagarinova, H Aoki, J Stockwell, M Jessulat, F Goebels, K Broderick, NE Scott, J Vlasblom, G Musso, B Prasad, E Lamantea Show all
Iscience | CELL PRESS | Published : 2019
Abstract
Biological Sciences; Developmental Neuroscience; Developmental Biology; Proteomics
Grants
Awarded by Saskatchewan Health Research Foundation
Funding Acknowledgements
We thank Dr. Khaled Aly for helpful discussions; the Centre for Applied Genomics facility and SPARC Bio-centre at the Hospital for Sick Children, Toronto, for their help with bulk RNA-seq and Seahorse XF analyzer; Vanderbilt University Medical Center for scRNA-seq; and "Cell lines and DNA Bank of Movement Disorders and Neurodegenerative Diseases" of the Telethon Network of Genetic Biobanks and the Euro-BioBank network for providing patient fibroblasts with CIV deficiency and mutations in NDUFS1/V1 and PINK1. M.T.M., R.M., J.V., and M.J. were supported by a Saskatchewan Health Research Foundation Postdoctoral Fellowship, and A.G. is supported by a Canadian Institutes of Health Research (CIHR) postdoctoral fellowship. M.B. is a CIHR New Investigator (MSH-130178). This work was supported by grants from HSFC Grant-in-Aid to F.S.C. (G-16-00014633), CIHR to L.J.F. (MOP-77688) and M.B. (MOP-125952; RSN-124512, 132191; FDN-154318), as well as the ARSACS Foundation Parkinson Society Canada (2014-673) and National Institutes of Health (R01GM106019) to M.B.