Epha2 genotype influences ultraviolet radiation induced cataract in mice
Alpana Dave, Jamie E Craig, Karina Skrzypiec, Stephen Quinn, Mary Barnes, Nick Di Girolamo, David A Mackey, Kathryn P Burdon, Robb U de Iongh, Shiwani Sharma
Experimental Eye Research | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2019
Age-related cataract is the major cause of blindness worldwide. Both genetic and environmental factors contribute to the disease. Genetic variation in the Ephrin type-A receptor 2 (EPHA2) gene is associated with the risk of age-related cataract in multiple populations, and exposure to ultraviolet-B (UV-B) radiation is a well-established risk factor for the disease. Epha2 knockout and UV-B radiation independently lead to cataract in mice, and UV-B radiation reportedly alters EPHA2 expression in cultured cells. We hypothesised that an interaction between UV-B radiation exposure and Epha2 signalling may influence cataract development. To test this hypothesis, 5-week-old Epha2+/+ and Epha2+/- mi..View full abstract
Awarded by National Health and Medical Research Council (NHMRC), Australia
This work was funded by the National Health and Medical Research Council (NHMRC), Australia (grant#GNT11009955), and the Flinders Medical Centre Foundation and Flinders University, South Australia, Australia. JEC and KPB are recipients of NHMRC Practitioner and Senior Research Fellowships, respectively.