Gardnerella vaginalis Clade Distribution Is Associated With Behavioral Practices and Nugent Score in Women Who Have Sex With Women
Erica L Plummer, Lenka A Vodstrcil, Gerald L Murray, Christopher K Fairley, Jennifer A Danielewski, Suzanne M Garland, Eric PF Chow, Dieter M Bulach, Katherine A Fethers, Jane S Hocking, Catriona S Bradshaw
The Journal of Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2020
BACKGROUND: Gardnerella vaginalis is detected in women with and without bacterial vaginosis (BV). Identification of 4 G. vaginalis clades raised the possibility that pathogenic and commensal clades exist. We investigated the association of behavioral practices and Nugent Score with G. vaginalis clade distribution in women who have sex with women (WSW). METHODS: Longitudinal self-collected vaginal specimens were analyzed using established G. vaginalis species-specific and clade-typing polymerase chain reaction assays. Logistic regression assessed factors associated with detection of G. vaginalis clades, and multinomial regression assessed factors associated with number of clades. RESULTS: Cla..View full abstract
Awarded by Australian National Health and Medical Research Council
This work funded by The Australian National Health and Medical Research Council Project Grant (1020457; to C. S. B.) and the Australian National Health and Medical Research Council Program Grant (1071269; to S. M. G. and C. K. F.). E. L. P. was supported by an Australian Government Research Training Program Scholarship.