Radiosynthesis and preliminary in vivo evaluation of F-18-labelled glycosylated duramycin peptides for imaging of phosphatidylethanolamine during apoptosis
Mohammad B Haskali, Delphine Denoyer, Peter D Roselt, Rodney J Hicks, Craig A Hutton
MEDCHEMCOMM | ROYAL SOC CHEMISTRY | Published : 2019
Duramycin derivatives incorporating an [18F]-labelled prosthetic group and one or two hydrophilic sugar amino acid moieties have been prepared as potential tracers for imaging of phosphatidylethanolamine during apoptosis. [18F]FP-digalacto-duramycin exhibited a low Logd, high renal clearance and low background activity and is a promising radiotracer for tracking apoptosis in vivo.
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Awarded by ARC
Awarded by NHMRC Practitioner Fellowship
We acknowledge award of a PhD scholarship by the CRC for Biomedical Imaging to M. H., and funding from ARC DP DP120101454. Professor Hicks is the recipient of a NHMRC Practitioner Fellowship (APP1108050).