Journal article

Radiosynthesis and preliminary in vivo evaluation of F-18-labelled glycosylated duramycin peptides for imaging of phosphatidylethanolamine during apoptosis

Mohammad B Haskali, Delphine Denoyer, Peter D Roselt, Rodney J Hicks, Craig A Hutton

MEDCHEMCOMM | ROYAL SOC CHEMISTRY | Published : 2019

Abstract

Duramycin derivatives incorporating an [18F]-labelled prosthetic group and one or two hydrophilic sugar amino acid moieties have been prepared as potential tracers for imaging of phosphatidylethanolamine during apoptosis. [18F]FP-digalacto-duramycin exhibited a low Logd, high renal clearance and low background activity and is a promising radiotracer for tracking apoptosis in vivo.