Journal article

Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3

Emma J Petrie, Jarrod J Sandow, Wil IL Lehmann, Lung-Yu Liang, Diane Coursier, Samuel N Young, Wilhelmus JA Kersten, Cheree Fitzgibbon, Andre L Samson, Annette V Jacobsen, Kym N Lowes, Amanda E Au, Helene Jousset Sabroux, Najoua Lalaoui, Andrew I Webb, Guillaume Lessene, Gerard Manning, Isabelle S Lucet, James M Murphy

Cell Reports | CELL PRESS | Published : 2019


Awarded by National Health and Medical Research Council

Awarded by Victorian Cancer Agency

Funding Acknowledgements

We thank the Walter and Eliza Hall Institute Monoclonal Antibody Facility for their assistance generating the anti-human and anti-mouse RIPK3 antibodies. We are grateful to the National Health and Medical Research Council for fellowship (G.L., 1117089; and J.M.M., 1105754), grant (1124735 and 1124737), and infrastructure (IRIISS 9000433) support and the Victorian Cancer Agency for fellowship support (N.L., 17030), with additional support from the Australian Cancer Research Foundation and the Victorian Government Operational Infrastructure Support scheme. We acknowledge Melbourne Research Scholarship support for L.-Y.L. from the University of Melbourne and support of an Australian Research Training Program Scholarship to A.V.J. We thank Kim Newton and Vishva Dixit for Ripk3<SUP>-/-</SUP> mice, from which MDF cells were derived, and the phospho-mouse RIPK3 antibody; Maria Tanzer for RIPK3<SUP>-/-</SUP> U937 cells; and Toru Okamoto for the pFTRE3G PGK Puro vector.