Screening circulating proteins to identify biomarkers of fetal macrosomia.
Tess Cruickshank, Tu'uhevaha J Kaitu'u-Lino, Ping Cannon, Alesia Harper, Tuong-Vi Nguyen, Kirsten M Dane, Anna L Middleton, Valerie P Kyritsis, Roxanne Hastie, Stephen Tong, Susan P Walker, Teresa M MacDonald
BMC Research Notes | BioMed Central | Published : 2019
OBJECTIVE: Fetal macrosomia is a major risk factor for shoulder dystocia, which can lead to birth asphyxia, maternal and neonatal traumatic injuries, and perinatal death. If macrosomia is diagnosed in the antenatal period, labour can be induced to decrease shoulder dystocia. But current clinical methods to diagnose fetal macrosomia antenatally perform with poor accuracy. Therefore, improved methods to accurately diagnose fetal macrosomia are required. Blood biomarkers that predict fetal macrosomia could be one such novel diagnostic strategy. We undertook a nested case-control study from a prospective collection of 1000 blood samples collected at 36 weeks' gestation. We analysed plasma sample..View full abstract
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Awarded by National Health and Medical Research Council
Awarded by RANZCOG Research Foundation
Funding for this work was provided by the National Health and Medical Research Council (#1065854), Foresight Health, The Stillbirth Foundation and the Norman Beischer Medical Research Foundation; Australian Government Research Training Program Scholarship, and RANZCOG Taylor Hammond Scholarship to TM; National Health and Medical Research Council Fellowships to TKL (#1159261), ST (#1136418).