Sets of coregulated serum lipids are associated with Alzheimer's disease pathophysiology.
Dinesh Kumar Barupal, Rebecca Baillie, Sili Fan, Andrew J Saykin, Peter J Meikle, Matthias Arnold, Kwangsik Nho, Oliver Fiehn, Rima Kaddurah-Daouk, undefined Alzheimer Disease Metabolomics Consortium
Alzheimer's & Dementia Diagnosis Assessment & Disease Monitoring | Published : 2019
Introduction: Comorbidity with metabolic diseases indicates that lipid metabolism plays a role in the etiology of Alzheimer's disease (AD). Comprehensive lipidomic analysis can provide new insights into the altered lipid metabolism in AD. Method: In this study, a total 349 serum lipids were measured in 806 participants enrolled in the Alzheimer's Disease Neuroimaging Initiative Phase 1 cohort and analyzed using lipid-set enrichment statistics, a data mining method to find coregulated lipid sets. Results: We found that sets of blood lipids were associated with current AD biomarkers and with AD clinical symptoms. AD diagnosis was associated with 7 of 28 lipid sets of which four also correlated..View full abstract