Overcoming nature's paradox in skeletal muscle to optimise animal production

GS Lynch; R Koopman

Journal article

Overcoming nature's paradox in skeletal muscle to optimise animal production

GS Lynch, R Koopman

Animal Production Science | CSIRO PUBLISHING | Published : 2019

DOI: 10.1071/AN19361

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Abstract

Nature's paradox in skeletal muscle describes the seemingly mutually exclusive relationship between muscle fibre size and oxidative capacity. In mammals, there is a constraint on the size at which mitochondria-rich, high O2-dependent oxidative fibres can attain before they become anoxic or adapt to a glycolytic phenotype, being less reliant on O2. This implies that a muscle fibre can hypertrophy at the expense of its endurance capacity. Adaptations to activity (exercise) generally obey this relationship, with optimal muscle endurance generally being linked to an enhanced proportion of small, slow oxidative fibres and muscle strength (force and/or power) being linked to an enhanced proportion..

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University of Melbourne Researchers

Gordon Lynch Author

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Grants

Awarded by Cancer Council Victoria

Funding Acknowledgements

We are grateful for research grant support from the Australian Research Council (DP190101937, DP150100206), the National Health and Medical Research Council (GNT1144772, GNT1124474, GNT1120714, GNT1065456), the Duchenne Parent Project, The Netherlands (18.015), and Cancer Council Victoria (APP1120752).